Patients should be reevaluated periodically as clinically appropriate (for example at 3-month to 6-month intervals) to determine if treatment is still necessary (see BOXED WARNINGS and WARNINGS). To reduce the development of drug-resistant bacteria and maintain the effectiveness of OXYCONTIN and other antibacterial drugs, OXYCONTIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. What is the most important information I should know about FOSAMAX? The concurrent use of oxycontin and an NSAID does increase the risk of serious GI events (see Gastrointestinal Effects - Risk of Ulceration, Bleeding, and Perforation). In the treatment of ?-hemolytic streptococcal infections, a therapeutic dosage of Keflex should be administered for at least 10 days. Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of oxycontin and thiazides in some patients. In these 3 studies, PROZAC 60 mg, but not 20 mg, was statistically significantly superior to placebo in reducing the number of binge-eating and vomiting episodes per week. It is important to only use a catheter tipped syringe when administering OXYCONTIN through a nasogastric tube. Altered anticoagulant effects, including increased bleeding, have been reported when SSRIs and SNRIs are coadministered with warfarin. In addition, patients treated with OXYCONTIN reported less day and nighttime heartburn and took less antacid tablets for fewer days than patients taking ranitidine 150 mg twice daily. You should stop taking this medicine and consult your doctor immediately or seek emergency medical care if your baby shows any of the symptoms just mentioned. Physicians should instruct their patients to read the patient package insert before starting therapy with OXYCONTIN and to reread it each time the prescription is renewed. This is not a complete list of possible side effects. In a recent retrospective study of 306 patients admitted for oxycontin overdose, 6.9% had severe liver injury but all recovered.